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Fc Fusion Protein Technology
An **Fc fusion protein** is a complex, engineered therapeutic molecule created by genetically linking a protein or peptide of therapeutic interest (the 'payload') to the **Fc domain** (Fragment crystallizable region) of an immunoglobulin G (**IgG**) antibody. This structural modification is a powerful strategy in protein engineering, designed to bestow the fused therapeutic molecule with the desirable pharmacological properties of the antibody, principally a significantly extended circulatory **half-life** and enhanced stability. This results in the need for less frequent patient dosing, greatly improving convenience and adherence to therapeutic regimens for chronic conditions.
The key to the success of Fc fusion technology lies in the unique relationship between the Fc domain and the **Neonatal Fc Receptor (FcRn)**. In the body, antibodies are protected from rapid degradation by being internalized into cells and binding to FcRn. Instead of being trafficked to the lysosome for breakdown, the FcRn complex recycles the antibody back to…
